The Eli and Edythe L. Broad Institute of Harvard and MIT is founded on two core beliefs: This generation has a historic opportunity and responsibility to transform medicine by using systematic approaches in the biological sciences to dramatically accelerate the understanding and treatment of disease. To fulfill this mission, we need new kinds of research institutions, with a deeply collaborative spirit across disciplines and organizations, and having the capacity to tackle ambitious challenges. The Broad Institute is essentially an “experiment” in a new way of doing science, empowering this generation of researchers to: Act nimbly. Encouraging creativity often means moving quickly,